Ive run 2stroke oil in my 06 cummins 2500 4x4 since it had 40k miles on it. Bought the truck new in Dec of 05. About 200k miles using it now after that. Use a baldwin fuel filter. Hypertech on highest setting. Pull a 32 ft gooseneck loaded pretty often. 38" tires. No negative effects. Knock on wood, ive never touched any part in my motor or fuel system. Hopefully ill see another 200k plus on stock parts using it.